Thyroid Science
A journal dedicated to truth in thyroid science and clinical practice

ABOUT US | Home | Journal Staff | Editorial & Latest Postings | Search Engine |
SUBMISSIONS | Authors' Guidelines | How to Submit Papers | How Submit Letters |
SECTIONS | Criticism | Case Reports | Debate | Clinical & Lab Studies | Hypotheses | Letters | Reviews |

Thyroid Science 11(1):CLS1-18, 2007

Metabolic Failure as the Cause of Fibromyalgia Syndrome: Exploring the John C. Lowe Thesis
(Full Text Free in pdf format)

Bjørn Johan Øverbye, MD*

*Postbox 348 –N4803, Arendal, Norway, Contact:

Abstract. Introduction and Aim. The aim of this one year project was to investigate a thesis by John C. Lowe: that fibromyalgia syndrome (FMS) is a hypometabolic condition caused by a reduced effect of thyroid hormones at the cellular level, due either to (1) a deficiency of adequate thyroid hormone (hypothyroidism), or (2) a reduced cellular effect of thyroid hormone despite its production of reference range quantities (partial peripheral thyroid hormone resistance).

Material and Methods. Study subjects were 56 female patients with a clinical picture of "classical FMS." The diagnosis of FMS was verified by specialists for 27 of the patients. Although 29 patients had the classical signs and symptoms of FMS, they were waiting for their diagnosis to be verified by specialists. These 29 patients were excluded from the investigation until a later date when a qualified specialist will verify beyond doubt their correct diagnostic label.

To test Lowe’s thesis, a questionnaire was made. The basis of the questionnaire was the already-existing statistics of symptoms and signs of hypothyroid patients who had not yet achieved metabolic restoration by the use of thyroid hormone medication. The questionnaire was filled out by all 56 patients. The answers from all patients were collected and put into a database. The answers of patients with verified FMS were extracted and compared to the statistical material upon which the questionnaire was made.

In addition, all 27 patients with verified FMS were tested for their thyroid hormone status at the local hospital. Thirteen of the patients were tested with a method developed by Professor Louis-Claude Van Vincent,[45] "Van Vincent’s Bio-Electrical-Terrain-Analysis" (Van Vincent BE-T-A). BE-T-A is a system that evaluates the metabolic status of mesenchymal (structurally supportive) and parenchyma (essentially producing) tissues.[16]

Results. Comparing the questionnaire answers of the 27 FMS patients with the statistics from hypothyroid patients, the frequencies of symptoms fit a pattern of untreated hypothyroidism. The Van Vincent BE-T-A test showed an acidosis of mesenchymal tissues, such as connective tissues and lymphatic and blood vessels. The acidosis can be explained by a lack of thyroid hormone effect at the cellular level, leading to an increase in parenchymal anaerobic metabolism, in which biological processes proceed in the absence of oxygen.

Conclusion. The results of questionnaire analysis, use of the Van Vincent BE-T-A testing, and the author's clinical experience are consistent with the Lowe thesis that metabolic failure underlies FMS. The cause of the failure is plausibly explained by deficiencies of thyroid hormones or reduced cellular effects of the hormones. There are two natural solutions to this problem: (1) increase the amount of thyroid hormones available to the tissues, and (2) normalize the cellular effects of thyroid hormones by removing whatever hinders their normal effects.

KEYWORDS: Fibromyalgia syndrome, hypothyroidism, thyroid hormone resistance, Van Vincent BE-T-A test, Bio-Electrical–Terrain-Analysis, energy medicine, John C. Lowe Thesis

Bjørn Johan Øverbye. Metabolic Failure as the Cause of Fibromyalgia Syndrome:
Exploring the John C. Lowe Thesis. Thyroid Science, 11(1):CLS1-18, 2007.
(Full Text Free in pdf format)

2007 Thyroid Science