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Thyroid Science 4(3):CLS1-5, 2009

Thyroid Hormone Changes in
Pregnant and Non-Pregnant Women:
A Case-Control Study

(Full Text Free in pdf format)

P.Pasupathi,1* V. Chandrasekar,2 and U. Senthil Kumar,3

1Department of Clinical Biochemistry,
2Department of Microbiology,
3Department of Laboratory Medicine,
Bio Line Research Institute,
Coimbatore-641 014, Tamil Nadu, India

*Corresponding author: Dr. P. Pasupathi, Ph.D.,
Head-Department of Clinical Biochemistry,
Bio Line Research Institute, Coimbatore-641 014 Tamil Nadu, India
Tel: +91 422 4270509 Fax: +91 422 4520099

. Pregnancy is associated with significant but reversible changes in thyroid function tests results, which are among the most profound seen as a result of a normal physiologic state. The present study was carried out to find out alterations in thyroid function tests in each trimester in normal pregnant women as compared to non-pregnant women. Methods: A case-control study designed with two groups of women: (1) 75 normal pregnant women randomly selected from the first (25 samples), the second (25 samples), and the third (25 samples) trimesters, and (2) 75 randomly selected non-pregnant healthy female controls. Thyroid function tests were carried out by measuring the serum levels of thyroid stimulating hormone (TSH), free and total thyroxin (FT4, T4), and free and total triiodothyronine (FT3, T3) by commercially available radio-immunoassay kits. Results: We found that mean T4 increased progressively during pregnancy. Serum levels of T3 increased in the second trimester and then declined during the third trimester compared with non-pregnant women. We also found that FT4 strongly decreased during the third trimester. Free T3 declined in the second and third trimesters. The mean TSH did not significantly differ in the three trimesters compared to the levels of non-pregnant women. Conclusion: Thyroid function tests in pregnancy should be interpreted against gestational age-related reference intervals to avoid misinterpretation of thyroid function during pregnancy.

Keywords. FT3 FT4 Pregnancy T3 T4 TSH

Pasupathi,P., Chandrasekar, V., and Senthil Kumar, U.: Thyroid Hormone Changes in Pregnant and Non-Pregnant Women: A Case-Control Study. Thyroid Science, 4(3):CLS1-5, 2009.

(Full Text Free in pdf format)

2009 Thyroid Science