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Thyroid Science 5(2):CLS1-5, 2010

Study of Thyroid Auto-Antibodies in Patients
with Bronchial Asthma and Allergic Rhinitis

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Mohammed Fahamy Abd El-Aziz,1 Maged Mohamed Rafaat,2
Inas Mohamed Sabry,1* Mohamed Yousef,3 Amira Mandour4

1Endocrine and Diabetes Unit, Internal Medicine Department, Ain Shams University,
2Allergy Unit, Internal Medicine Department, Ain Shams University,
3Clinical Pathology Department, Ain Shams University,
4Misr University for Technology and Science, Cairo, Egypt.

*Corresponding Author: Inas Mohamed Sabry Mohamed El Nabrawy MD,
Endocrine unit, Internal Medicine Department, Ain Shams University Hospitals,
Faculty of Medicine, Ain Shams University. Abbassia, Cairo; Egypt.
Address: 8 Nasr Street, 1st May Buildings, Nasr City; Cairo, Egypt.
Tel: +2 0101780318 Fax: +2. 24845647

Abstract. Background:
Few reports stated that autoimmunity in patients with allergic rhinitis had increased frequency of Grave's disease. Moreover, it had been clarified that the association of seasonal allergic rhinitis was frequent in Grave's disease and rare in painless thyroiditis. Little is known about relation between thyroid disease and allergic diseases. Aim of the Work: is to study of coexistence of thyroid auto-antibodies in patients with bronchial asthma and allergic rhinitis. Methods: 40 patients with allergic diseases (20 patients with bronchial asthma [BA], and 20 patients with allergic rhinitis [AR]) and 20 healthy control subjects were included in the study. Free triiodothyronine (FT3), free thyroxin (FT4) by radioimmunoassay (RIA) and thyroid stimulating hormone (TSH); Thyroid auto-antibodies [anti-thyroid peroxidase (anti-TPO)and anti-thyroglobulin (anti-TG) ] by Enzyme- linked Immunosorbent Assay (ELISA); complete blood picture; allergic skin tests; and peak expiratory flow rate measured by spirometry were done. Results: Thyroid auto-antibodies levels were higher in patients with BA and AR in comparison with healthy subjects (P < 0.05). While, there was no significant difference as regard thyroid profiles (FT3, FT4, and TSH). Also, there was non significant difference as regards thyroid auto-antibodies were found between BA and AR (P > 0.05). Conclusion: Autoimmune process may be associated with allergic disease but this is not enough to induce changes in thyroid profiles.

Keywords Anti-thyroglobulin Anti-thyroid peroxidase antibody Allergic diseases thyroid hormones IgE

El-Aziz, M.F.A., Rafaat, M.M., Sabry, I.M., Yousef, M., and Mandour, A.:
Study of Thyroid auto-antibodies in patients with bronchial asthma and
allergic rhinitis. Thyroid Science, 5(2):CLS1-5, 2010.

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2010 Thyroid Science