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  Thyroid Science 6(4):1-9, 2011

The Impact of Diabetes on Thyroid Dysfunction and
Outcomes in a Native Indian Female Population

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Nima V. Thakkar, PhD and Sunita M. Jain, PhD

Department of Pharmacology, L.M.,
College of Pharmacy, Ahmedabad-380009, Gujarat, India

Corresponding Author: Dr. Nima Thakkar
Postal Address: Department of Pharmacology, L.M.
College of Pharmacy, Gujarat University, Navarangpura, Ahmedabad. 380009
Facsimile number: +91-9769995520 E-mail Address:

Abstract. Introduction: In the present study, the prevalence and pattern of thyroid dysfunction in an Indian female population with type 2 diabetes mellitus (T2D) were assessed. The aim was to find the correlation and comparison between these two major metabolic disorders. Methods: The study was a population-based survey of the prevalence of thyroid dysfunction in the T2D population. Participants in the study were 137 eligible females aged between 30-to-70 years. The biochemical parameters were body mass index (BMI), glycemic control (fasting and post prandial blood glucose levels, glycated haemoglobin A1c), and a thyroid profile (TSH, free T3, and free T4). These parameters were measured and compared with the normal population. Medication compliance was also considered. Results: Patients taking medications for both the conditions (T2D and hypothyroidism[HO]) showed controlled biochemical investigations compared to patients suffering from individual disorders; patients with both disorders had therapeutic stability. Conclusion: This study suggests that in the female population, T2D and HO are prevalent both individually and jointly. Further, there seems to be a good comparison between patients who have one of the metabolic disorders and those who have only one of them. The significant correlation positive between insulin use by T2D patients and disease complications was positive, and the correlation between hyperthyroidism and BMI was significantly negative. Age positively correlated with HbA1c and T2D duration. A significant correlation between T2D and HO was not established in this study. However, unsuspected/undiagnosed HO may be a matter of consideration for T2D patients.

Keywords type 2 diabetes hypothyroidism metabolic disorder prevalence body mass index

Citation: Thakkar, N.V. and Jain, S.M.: The impact of diabetes on thyroid dysfunction and outcomes in a native Indian female population. Thyroid Science, 6(4):1-9, 2011.

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2011 Thyroid Science